New 4-aminoquinolines as moderate inhibitors of P. falciparum malaria

Synthesis of novel aminoquinoline derivatives has been accomplished and their activity against malaria strains examined. The compounds showed moderate in vitro antimalarial two P. falciparum strains, 3D7 (CQ susceptible clone) Dd2 resistant clone). Three aminoquinolines were further examined for efficacy a mouse model using modified Thompson test. In this model, mice infected with berghei-infected red blood cells, drugs administered orally. Antimalarial 3 was found toxic at dose 320 (mg/kg)/day 3/6 mice, however, 2/6 the same group survived through day 31, one them cured.